The principal cytochrome P450 isoenzyme concerned appears for being CYP2E1, with CYP1A2 and CYP3A4 as more pathways. Close to 85% of an oral dose appears while in the urine inside 24 hours of administration, most given that the glucuronide conjugate, with little amounts of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity informatio